The Daihannya-kyō (Mahāprajñāpāramitā sūtra) is a grand Buddhist scripture which was translated into Chinese in 663 by Priest Genjō (Xuan Zhuang) during the Tang dynasty in China. This sutra is popular and is often recited for the purpose of preventing misfortune and acquiring happiness. In Japan this sutra has often been copied during the long period between the Nara period and the end of the Edo period. It was printed, too.
The particular scroll introduced in this article had been kept in Yakushi-ji temple. The letter size is rather large and therefore the lines of the sutra look massive. It is one of the scrolls that are called "Gyoyō-kyō" as it was reportedly copied by master calligrapher Tomono Uokai (the name "Uokai" can be pronounced "Gyoyō", too). Until today, more than 480 copies of Gyoyō-kyō sutras have been found in Japan. Judging from the inscriptions at the end of those Gyoyō-kyō sutras, those scrolls were made at the governmental studio for sutra copying sometime around 770.
A seal which reads "Seal of Yakushi-ji Temple" is stamped at two places in red over the inscription at the beginning of the scroll, and another seal which reads "Kondō Hall of Yakushi-ji Temple" is stamped in black onto the reverse side of the first sheet and the eighteenth sheet. The ends of the scroll-core are coated with white color. 
Masterpieces of Nara National Museum. Nara National Museum, 1993, pp.78-79, no.59.